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Comparative effects of pharmacological, psychological, and neurostimulatory interventions for ADHD in adults: a systematic review and network meta-analysis

Attention Deficit Hyperactivity Disorder (ADHD) was once thought to be a childhood disorder only. However, it is now well-known that ADHD can persist into adulthood, affecting approximately 2.5% of the general adult population worldwide. Treatment options for individuals with ADHD include medication and non-pharmacological approaches, such as psychotherapy. Over the past few years, there has been a growing number of trials on adults with ADHD and there is a pressing need to better understand how to manage these patients.

This new study, which was published in the Lancet Psychiatry, is a comprehensive systematic review and component network meta-analysis which has compared  available drugs and non-pharmacological interventions (such as, cognitive behavioural therapy, cognitive remediation, mindfulness, psychoeducation, and transcranial direct current stimulation) for the treatment of ADHD in adults, in terms of symptom severity, executive dysfunction (e.g., working memory problems), emotional dysregulation, quality of life and side effects.

Researchers included 113 RCTs, comprising 14,887 participants, allocated to one of 16 active interventions (pharmacological therapies, psychological therapies, neurostimulatory therapy and neurofeedback) or a control condition. 

Journalists came to this hybrid briefing to hear from authors of the study and put their questions to them.

 

Speakers included:

Professor Andrea Cipriani, Professor of Psychiatry, University of Oxford and Director of the NIHR Oxford Health Clinical Research Facility

Dr Edoardo Ostinelli, Deputy Lead, Oxford Precision Psychiatry Lab, University of Oxford

Professor Samuele Cortese, Professor of Child and Adolescent Psychiatry, University of Southampton and Chair of the European ADHD Guidelines Group

Professor Alexandra Pjilkopsen, Director of the Department of Psychiatry and Psychotherapy at the University Hospital Bonn

Ms Andrea Bilbow, CEO of ADDISS, The National Attention Deficit Disorder Information and Support Service

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